SANGKURIANG CATFISH (CLARIAS GARIEPINUS VAR) SKIN EXTRACT ACTIVITY ON FIBROBLAST AND COLLAGEN SYNTHESIS FOR SKIN BURN HEALING

Ary Andini1, Retno Handajani, Soetjipto

Abstract


Background: Burn healing of IIb degree requires a relatively longer time for healing
followed by hypertrophic scar formation. Sangkuriang catfish (Clarias gariepinus var) skin
extract topical contains amino acids of collagen. Collagen is the main component of skin
wound healing. The aim of this research was to determine the influence of Sangkuriang
catfish skin extract topical treatment on fibroblast and collagen synthesis for burn healing
Methods: Sangkuriang catfish skin was extracted using HCl 2% for 48 hours and neutralized
by NaOH 1 M. Twenty-eight male Rattus novergicus strain Wistar were used for this
researchwere, divided into K3, P3, K10, and P10 groups. Each member of group was
subjected with IIb degree burn injury on the back, then K3 and K10 groups were treated by
using aquades topically twice a day whereas P3 and P10 groups tpicaly treated with
Sangkuriang catfish skin extract twice a day.
Results: Sangkuriang catfish skin extract topical treatment increase fibroblast number and
significant extensive collagen percentage on 10th day
Conclusion: Topical treatment of Sangkuriang catfish skin extract could accelerate burn
healing by increasing number of fibroblast and percentage of extensive collagen.
Keywords: Sangkuriang Catfish, Collagen, Fibroblast, Burn Healing


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