PENETUAN FORMULA UNTUK MENETAPKAN ESTIMASI KOLESTEROL-LDL

Gilang Nugraha, Soebagijo Poegoeh Edijanto

Abstract


Measurement LDL-Cholesterol (LDL-C) can be performed by estimating LDL-C (cLDL-C) in
the blood. In addition to the first proposed Friedewald formula, several new formulas that promise better
examination in determining LDL-C levels, proposed by Anandaraja, Puavilai, Chen, Vujovic, de
Cordova and Dansethakul. The subjects of the study were patients who performed routine lipid profile
examination in Institution of Clinical Pathology of Gedung Pusat Diagnostik Terpadu RSUD Dr.
Soetomo Surabaya who performs 10 to 12 hours of fasting with TG less than 400 mg / dL. The sample
consisted of 41 men and 48 women with an average age of 52 years. The statistical test on each cLDLC
gave
the
Friedewald
-1.32%
bias
value;
Anandaraja
-3,92%;
Puavilai
4.26%,
Chen
-2.19%;
Vujovic

-23.65%;

de Cordova -0.91% and Dansethakul 4.45%. The correlation coefficient on Friedewald
0.9509; Anandaraja 0.9013; Puavilai 0.9576, Chen 0.9585; Vujovic 0.8745; de Cordova 0.9300 and
Dansethakul 0.9505. The proposed cLDL-C formula Chen et al promises in determining the LDL-C
estimate and the Vujovic formula gives a poor result in this study. Validation methods should be applied
to each of the cLDL formulas if they are to be applied to clinical laboratories


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